Reasonable Rascal
01-26-03, 22:54
VRE - PAKISTAN (KARACHI)
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A ProMED-mail post
Date: Sun, 26 Jan 2003
From: ProMED-mail <promed@promedmail.org>
Source: NewsRx.com & NewsRx.net [edited]
Emergence of Vancomycin-Resistant _E. faecium_ in Karachi, Pakistan
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According to a study from Pakistan, vancomycin-resistant enterococcus (VRE) has not been reported peviously in Pakistan until vancomycin-resistant _Enterococcus faecium_ was isolated from the clinical specimens of 6 patients admitted to the intensive care unit (ICU) and neonatal intensive care unit (NICU) of the Aga Khan University Hospital, Karachi.
"To identify the extent of the outbreak, rectal swabs were obtained from all the patients admitted to the ICU and NICU at that time. A total of 10 strains of vancomycin-resistant _Enterococcus faecium_ were isolated. All the strains showed high-level resistance to both glycopeptides (vancomycin and teicoplanin) with a vancomycin minimum inhibitory concentration greater than 256 mg/L. All isolates had the vanA gene detected by polymerase chain reaction. The contour-clamped homogeneous electric field (CHEF) pattern
demonstrated that all but one of the isolates were of a single clone, suggesting that they were derived from common source," stated E. Khan and colleagues, Aga Khan University Hospital.
Khan and colleagues concluded: "Use of vancomycin and prolonged hospitalization were common features in all cases investigated."
Khan and coauthors published the results of their study in the Journal of Hospital Infection (Emergence of vancomycin-resistant _Enterococcus faecium_ at a tertiary care hospital in Karachi, Pakistan. J Hosp Infect, 2002;52:292-296).
--
ProMED-mail
************************
A ProMED-mail post
Date: Sun, 26 Jan 2003
From: ProMED-mail <promed@promedmail.org>
Source: NewsRx.com & NewsRx.net [edited]
Emergence of Vancomycin-Resistant _E. faecium_ in Karachi, Pakistan
--------------------------------------------------
According to a study from Pakistan, vancomycin-resistant enterococcus (VRE) has not been reported peviously in Pakistan until vancomycin-resistant _Enterococcus faecium_ was isolated from the clinical specimens of 6 patients admitted to the intensive care unit (ICU) and neonatal intensive care unit (NICU) of the Aga Khan University Hospital, Karachi.
"To identify the extent of the outbreak, rectal swabs were obtained from all the patients admitted to the ICU and NICU at that time. A total of 10 strains of vancomycin-resistant _Enterococcus faecium_ were isolated. All the strains showed high-level resistance to both glycopeptides (vancomycin and teicoplanin) with a vancomycin minimum inhibitory concentration greater than 256 mg/L. All isolates had the vanA gene detected by polymerase chain reaction. The contour-clamped homogeneous electric field (CHEF) pattern
demonstrated that all but one of the isolates were of a single clone, suggesting that they were derived from common source," stated E. Khan and colleagues, Aga Khan University Hospital.
Khan and colleagues concluded: "Use of vancomycin and prolonged hospitalization were common features in all cases investigated."
Khan and coauthors published the results of their study in the Journal of Hospital Infection (Emergence of vancomycin-resistant _Enterococcus faecium_ at a tertiary care hospital in Karachi, Pakistan. J Hosp Infect, 2002;52:292-296).
--
ProMED-mail