tangent
12-15-01, 02:21
re: cadaver blood:
The US military is giving it a thumbs up for disaster use, and all the peer review medical journal articals indicate it works well. I have read several. Unfortunatly, the majority of the research on this topic is in russian.
as to coagulation, it doesn't need an anti-coagulant as blood goes through some strange changes post-mortem, returning to a liquid form. The research is quite interesting in this regard.
I will make 2 caveats: 1) I am in the preliminary stages of research on this topic and can only give you my initial impression, which is that I personally have found nothing published that is negative about it. 2) RESQDOC did mention coming across some reason that it would be a bad idea, but to date has not provided a journal reference for same. I'm undecided at the moment, but leaning to favorable, until such time as I locate a reason to believe otherwise.
---------------
This is a DRAFT biblio - additional papers are mentioned as references in the citations and I have only read a few of them, so far. 12/15/01
Kevorkian J, Bylsma G, Amer J Clin Path 1961 May 35(5):413-419 Transfusion of Postmortem Human Blood
--------
Shamov W, Lancet, 1937 Aug, 306-309, The Transfusion of Stored Transfusion Blood
--------
Yudin S, J.A.M.A., 1936 Mar, 106(12):997-999, Transfusion of Cadaver Blood
--------
Ferguson E, Shock and it's treatment, ch 20 in:
Disaster Medicine, Burke (ed), this book came out of the Uniformed Services Institute - where the military trains doctors, etc.
----------
Vestn Akad Med Nauk SSSR 1991;(9):18-24
[Biomedical aspects of the use of cadaver blood.]
[Article in Russian]
Khvatov VB.
The author analyzes historical periods during which Academician S. S. Yudin developed the theory of cadaveric blood and pioneered its practical implementation, storage and the clinical use. Demonstrates the efficacy of the new transfusion medium in the management of patients with emergency conditions. Reviews 3 trends in the investigations carried out in this area: in morbid anatomy and forensic medicine, in experimental and clinical transfusiology, and in biomedical studies. Provides evidence for the fact that blood plasma of sudden death victims and perfusate of the vessels are specific raw materials for obtaining plasmakinase, a fibrinolytic agent, and fibrinogen degradation products as well as another source for obtaining preparations with a directed action. Based on a large factual material, the author shows the possibility, importance, prospects and efficiency of the use of components, preparations and biologically active substances from cadaveric blood plasma.
PMID: 1750236 [PubMed - indexed for MEDLINE]
---------
Dtsch Med Wochenschr 1970 Mar 27;95(13):711-2
[Use of cadaver blood for blood transfusion.]
[Article in German]
Seidl S.
PMID: 5437139 [PubMed - indexed for MEDLINE]
-----------
Nippon Ketsueki Gakkai Zasshi 1971 Apr;34(2):219-27
Immunoelectrophoretic study on the Postmortem cadaver blood in sudden death.
Haba K.
PMID: 5170468 [PubMed - indexed for MEDLINE]
----------
J Forensic Med 1967 Oct-Dec;14(4):138-45
Fibrinolytic split products in cadaver blood from cases of sudn or violent death. An immuno-electrophoretic study.
Rabinovitz M, Schen RJ, Fisher IL.
PMID: 4966166 [PubMed - indexed for MEDLINE]
---------
Rev Invest Clin 1989 Jan-Mar;41(1):11-6
[Blood transfusion from cadavers.]
[Article in Spanish]
Vazquez-Valdes E, Marin-Lopez A, Velasco C, Herrera-Martinez E, Perez-Rojas A, Ortega-Rocha R, Aldama-Romano M, Murray J, Barradas-Guevara DC.
Most of the transplant programs in our days are based on cadaveric donation; blood has been not recovered from dead bodies, except by some Soviet groups. We selected 16 subjects, eight with brain death and eight with "biological" death (heart arrest) that were considered as ideal donors. From them we obtained 23 units of whole blood, either by surgical dissection of the internal jugular vein, by puncture of the femoral artery or by puncture of a peripheral arm vein. Twelve were not used due to bacterial growth, HBsAg positivity or hemolysis. Of the remaining, we obtained 10 packed red cells and 10 units of plasma, one unit was transfused as whole blood. Three plasma units were discharged due to "turbidity". Sixteen patients for whom it was difficult to get a voluntary donor were transfused with some of the products and followed for as long as they remained in hospital. None showed adverse reactions due to the procedure. We conclude that the organization of any program related to the transplantation of organs is not a simple matter, but that blood is easily recovered and that this should be done always as part of the "total use" of a donating body; cadaveric blood transfusion is harmless provided donors are carefully selected and that the sterility of the product is confirmed by culture.
PMID: 2727428 [PubMed - indexed for MEDLINE]
---------
Am J Forensic Med Pathol 1984 Sep;5(3):223-7
Fluidity of cadaveric blood after sudden death: Part I. Postmortem fibrinolysis and plasma catecholamine level.
Takeichi S, Wakasugi C, Shikata I.
In rats, fibrinolytic activity and plasma catecholamine levels increased rapidly after death. Postmortem fibrinolysis was affected by the method of sacrifice, but catecholamine level was not always affected. Immediately after death, the plasma adrenalin level was higher than the noradrenalin level, but then adrenalin remained unchanged or tended to decrease while noradrenalin tended to increase gradually with time. In human subjects after rapid death, the plasma catecholamine and fibrinolytic activity levels were high. However, in cases after slow death they were low.
PMID: 6496435 [PubMed - indexed for MEDLINE]
--------
Vestn Akad Med Nauk SSSR 1991;(9):27-30
[Use of fibrinolysis blood in patients with acute surgical diseases and injuries.]
[Article in Russian]
Chetverushkin BV, Stazhadze LL, Borovkova TF.
S. S. Yudin paid much attention to the use of cadaveric blood in urgent medicine. While transfusing large amounts of blood (2-3 1) for pre- and intraoperative correction of hypovolemia, the danger of isoimmune reaction is reduced. Blood circulation measurement fluctuations while using both cadaveric and donor's blood are similar. However, the use of cadaveric blood helps correct hypercoagulation caused by some anesthetics. Cadaveric blood can be substituted for donor's blood. Besides, large amounts of cadaveric blood can be used from the same donor, which provides economic effectiveness.
PMID: 1750238 [PubMed - indexed for MEDLINE]
------------
East Afr Med J 1995 Jun;72(6):341-2
Blood transfusion.
Riyat MS.
Publication Types: Editorial
PMID: 7497998 [PubMed - indexed for MEDLINE]
-----------
Voen Med Zh 1971 Feb;2:73-5
[Clinical use of cadaver blood preserved with sucrose solution and levomycetin.]
[Article in Russian]
Suvorova IA, Pafomov GA, Oldurova SV.
PMID: 5127297 [PubMed - indexed for MEDLINE]
------
Probl Gematol Pereliv Krovi 1971 Nov;16(11):38-42
[Blood of persons who died suddenly and its use in the treatment of patients with traumatic shock.]
[Article in Russian]
Pafomov GA, Zhilis BG.
PMID: 5149597 [PubMed - indexed for MEDLINE]
-------
EOF
The US military is giving it a thumbs up for disaster use, and all the peer review medical journal articals indicate it works well. I have read several. Unfortunatly, the majority of the research on this topic is in russian.
as to coagulation, it doesn't need an anti-coagulant as blood goes through some strange changes post-mortem, returning to a liquid form. The research is quite interesting in this regard.
I will make 2 caveats: 1) I am in the preliminary stages of research on this topic and can only give you my initial impression, which is that I personally have found nothing published that is negative about it. 2) RESQDOC did mention coming across some reason that it would be a bad idea, but to date has not provided a journal reference for same. I'm undecided at the moment, but leaning to favorable, until such time as I locate a reason to believe otherwise.
---------------
This is a DRAFT biblio - additional papers are mentioned as references in the citations and I have only read a few of them, so far. 12/15/01
Kevorkian J, Bylsma G, Amer J Clin Path 1961 May 35(5):413-419 Transfusion of Postmortem Human Blood
--------
Shamov W, Lancet, 1937 Aug, 306-309, The Transfusion of Stored Transfusion Blood
--------
Yudin S, J.A.M.A., 1936 Mar, 106(12):997-999, Transfusion of Cadaver Blood
--------
Ferguson E, Shock and it's treatment, ch 20 in:
Disaster Medicine, Burke (ed), this book came out of the Uniformed Services Institute - where the military trains doctors, etc.
----------
Vestn Akad Med Nauk SSSR 1991;(9):18-24
[Biomedical aspects of the use of cadaver blood.]
[Article in Russian]
Khvatov VB.
The author analyzes historical periods during which Academician S. S. Yudin developed the theory of cadaveric blood and pioneered its practical implementation, storage and the clinical use. Demonstrates the efficacy of the new transfusion medium in the management of patients with emergency conditions. Reviews 3 trends in the investigations carried out in this area: in morbid anatomy and forensic medicine, in experimental and clinical transfusiology, and in biomedical studies. Provides evidence for the fact that blood plasma of sudden death victims and perfusate of the vessels are specific raw materials for obtaining plasmakinase, a fibrinolytic agent, and fibrinogen degradation products as well as another source for obtaining preparations with a directed action. Based on a large factual material, the author shows the possibility, importance, prospects and efficiency of the use of components, preparations and biologically active substances from cadaveric blood plasma.
PMID: 1750236 [PubMed - indexed for MEDLINE]
---------
Dtsch Med Wochenschr 1970 Mar 27;95(13):711-2
[Use of cadaver blood for blood transfusion.]
[Article in German]
Seidl S.
PMID: 5437139 [PubMed - indexed for MEDLINE]
-----------
Nippon Ketsueki Gakkai Zasshi 1971 Apr;34(2):219-27
Immunoelectrophoretic study on the Postmortem cadaver blood in sudden death.
Haba K.
PMID: 5170468 [PubMed - indexed for MEDLINE]
----------
J Forensic Med 1967 Oct-Dec;14(4):138-45
Fibrinolytic split products in cadaver blood from cases of sudn or violent death. An immuno-electrophoretic study.
Rabinovitz M, Schen RJ, Fisher IL.
PMID: 4966166 [PubMed - indexed for MEDLINE]
---------
Rev Invest Clin 1989 Jan-Mar;41(1):11-6
[Blood transfusion from cadavers.]
[Article in Spanish]
Vazquez-Valdes E, Marin-Lopez A, Velasco C, Herrera-Martinez E, Perez-Rojas A, Ortega-Rocha R, Aldama-Romano M, Murray J, Barradas-Guevara DC.
Most of the transplant programs in our days are based on cadaveric donation; blood has been not recovered from dead bodies, except by some Soviet groups. We selected 16 subjects, eight with brain death and eight with "biological" death (heart arrest) that were considered as ideal donors. From them we obtained 23 units of whole blood, either by surgical dissection of the internal jugular vein, by puncture of the femoral artery or by puncture of a peripheral arm vein. Twelve were not used due to bacterial growth, HBsAg positivity or hemolysis. Of the remaining, we obtained 10 packed red cells and 10 units of plasma, one unit was transfused as whole blood. Three plasma units were discharged due to "turbidity". Sixteen patients for whom it was difficult to get a voluntary donor were transfused with some of the products and followed for as long as they remained in hospital. None showed adverse reactions due to the procedure. We conclude that the organization of any program related to the transplantation of organs is not a simple matter, but that blood is easily recovered and that this should be done always as part of the "total use" of a donating body; cadaveric blood transfusion is harmless provided donors are carefully selected and that the sterility of the product is confirmed by culture.
PMID: 2727428 [PubMed - indexed for MEDLINE]
---------
Am J Forensic Med Pathol 1984 Sep;5(3):223-7
Fluidity of cadaveric blood after sudden death: Part I. Postmortem fibrinolysis and plasma catecholamine level.
Takeichi S, Wakasugi C, Shikata I.
In rats, fibrinolytic activity and plasma catecholamine levels increased rapidly after death. Postmortem fibrinolysis was affected by the method of sacrifice, but catecholamine level was not always affected. Immediately after death, the plasma adrenalin level was higher than the noradrenalin level, but then adrenalin remained unchanged or tended to decrease while noradrenalin tended to increase gradually with time. In human subjects after rapid death, the plasma catecholamine and fibrinolytic activity levels were high. However, in cases after slow death they were low.
PMID: 6496435 [PubMed - indexed for MEDLINE]
--------
Vestn Akad Med Nauk SSSR 1991;(9):27-30
[Use of fibrinolysis blood in patients with acute surgical diseases and injuries.]
[Article in Russian]
Chetverushkin BV, Stazhadze LL, Borovkova TF.
S. S. Yudin paid much attention to the use of cadaveric blood in urgent medicine. While transfusing large amounts of blood (2-3 1) for pre- and intraoperative correction of hypovolemia, the danger of isoimmune reaction is reduced. Blood circulation measurement fluctuations while using both cadaveric and donor's blood are similar. However, the use of cadaveric blood helps correct hypercoagulation caused by some anesthetics. Cadaveric blood can be substituted for donor's blood. Besides, large amounts of cadaveric blood can be used from the same donor, which provides economic effectiveness.
PMID: 1750238 [PubMed - indexed for MEDLINE]
------------
East Afr Med J 1995 Jun;72(6):341-2
Blood transfusion.
Riyat MS.
Publication Types: Editorial
PMID: 7497998 [PubMed - indexed for MEDLINE]
-----------
Voen Med Zh 1971 Feb;2:73-5
[Clinical use of cadaver blood preserved with sucrose solution and levomycetin.]
[Article in Russian]
Suvorova IA, Pafomov GA, Oldurova SV.
PMID: 5127297 [PubMed - indexed for MEDLINE]
------
Probl Gematol Pereliv Krovi 1971 Nov;16(11):38-42
[Blood of persons who died suddenly and its use in the treatment of patients with traumatic shock.]
[Article in Russian]
Pafomov GA, Zhilis BG.
PMID: 5149597 [PubMed - indexed for MEDLINE]
-------
EOF